![]() Epigenetic memory in induced pluripotent stem cells. Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence. Variation in the safety of induced pluripotent stem cell lines. Broader implications of defining standards for the pluripotency of iPSCs. This study derived iPS cells from patients with a range of diseases, demonstrating the applications of iPS cells for disease modelling, pathogenesis studies and drug development.ĭaley, G. Disease-specific induced pluripotent stem cells. Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Differentiation of F1 embryonic stem cells into viable male and female mice by tetraploid embryo complementation. Developmental potential and behavior of tetraploid cells in the mouse embryo. iPS cells produce viable mice through tetraploid complementation. Adult mice generated from induced pluripotent stem cells. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. This study enumerated the molecular markers and functional criteria for defining reprogrammed cell populations.Ĭhan, E. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Guidelines and techniques for the generation of induced pluripotent stem cells. Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. New cell lines from mouse epiblast share defining features with human embryonic stem cells. A high-efficiency system for the generation and study of human induced pluripotent stem cells. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. ![]() Reprogramming of pancreatic β cells into induced pluripotent stem cells. Induced pluripotent stem cell lines derived from human somatic cells. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Reprogramming of human somatic cells to pluripotency with defined factors. Human oocytes reprogram somatic cells to a pluripotent state. ![]() Therapeutic cloning in individual parkinsonian mice. Lack of population diversity in commonly used human embryonic stem-cell lines. Ethics questions add to concerns about NIH lines. Embryonic stem cell lines derived from human blastocysts. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Establishment in culture of pluripotential cells from mouse embryos. The effect of cells transferred into the mouse blastocyst on subsequent development. Mouse chimeras obtained by the injection of cells into the blastocyst. Mosaic mice with teratocarcinoma-derived mutant cells deficient in hypoxanthine phosphoribosyltransferase. Experimentelle Erzeugung von Teil und Doppelbildungen. Der Wert der ersten beiden Furchungszellen in der Echinodermenentwickelung. This breakthrough paper describes the derivation of iPS cells directly from mouse somatic cells through the ectopic co-expression of reprogramming transcription factors, providing an alternative source of pluripotent cells for research.ĭreisch, H. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. ![]()
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